Unsigned handwritten notes in French by Louis Pasteur, two pages, 7.75 x 10.25, August 10, 1857. Pasteur's notes written based on his observations in the Swiss Alps, containing comparative information on diseases affecting silkworms compiled with the aid of a breeder, as well as information on epidemics affecting mulberry trees and vineyards. In fine condition.
Beginning in 1855, a widespread epidemic among silkworms nearly brought the French silk industry to ruin. As the crisis reached its peak in 1865, Pasteur—then serving as the professor of geology, physics, and chemistry at the École des Beaux-Arts in Paris—was asked by the Department of Agriculture to head a commission to investigate the devastating disease infecting the worms. Within five years, he had determined that temperature, humidity, ventilation, quality of the food, sanitation and adequate separation of the broods of newly hatched worms all played a role in susceptibility to the disease, and was able to create new methods breeding that would preserve healthy eggs and prevent contamination. An important topic in Pasteur's career, his research with the silkworms helped shape his future concepts on the influence of environment on contagion, leading to his most significant contributions in the study of causes and prevention of disease.
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