English scientist (1749–1823) who is widely credited as the pioneer of smallpox vaccine. Rare ink signature, “Yr ever affectionate E. Jenner,” on an off-white 5 x .5 slip clipped from a larger letter. In very good condition, with a complete separation through last letter of signature, which could be repaired, two other vertical folds, and scattered moderate toning. Pre-certified PSA/DNA and RR Auction COA.
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