American educator and physician (1728-1829) who contributed pioneering work in the advancement of smallpox vaccinations. Three items signed by Holyoke: an ADS signed "E. A. Holyoke," September 18, 1819, confirming receipt of a payment from Cushing Appleton; a manuscript DS signed "E. A. Holyoke," April 8, 1800, confirming that "Polly Chipman has remained in a very sick & feeble condition ever since the birth of her children"; and a manuscript DS signed "E. A. Holyoke," February 18, 1773, confirming receipt of a payment from Capt. Nicholas Thorndicke. In overall very good to fine condition.
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