French microbiologist and chemist who demonstrated the germ theory of disease and developed techniques of inoculation, most notably the first vaccine against rabies. ALS in French, signed “L. Pasteur,” one page, 4.5 x 5.25, no date. In French. Loosely translated, the letter reads, in part: “My children are sometimes cruel…I wanted to thank you…defend their excessive impudence. I have been touched by your charming sentiment. Please receive this with my affection and gratefulness.” The letter is beautifully double-matted and framed with a profile image of Pasteur, to an overall size of 19.5 x 15. In fine condition, with a couple of edge chips, a small tear at upper left,. COA John Reznikoff/PSA/DNA and R&R COA.