British biochemist (1918–2013) who won the Nobel Prize in Chemistry twice: once in 1958 for his work on the structure of proteins, and once in 1980 for his contributions concerning the determination of base sequences in nucleic acids. Handwritten manuscript by Sanger, unsigned, one page, 8.5 x 11, no date. Third page from a draft for an article, with sections headed “DNA sequencing” and “Direct sequencing by partial degradation,” in part: “The two main difficulties which have hitherto precluded any extensive sequencing of DNA are the very large size of all DNA molecules and the apparent lack of suitable enzymes for their specific degradation.” In fine condition.
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