British author (1785-1859) best remembered for his now-classic memoir of his experiments with drugs, Confessions of an English Opium-Eater. ALS signed “T. de Q.,” one page both sides, 4.5 x 7, October 19. Handwritten letter to Thomas Constable in Edinburgh, in part: "I was utterly at a loss how to proceed this morning from absolute inability to get over. But your messenger has made it poss. to suggest a resource. To-morrow morn'g at 1/2 past 8 a friend's carriage calls here to carry me into Edinburgh. From the Surgeon, who I see at a quarter past 9, I will come to Thistle Street…I send two distinct portions or sequences of copy: one marked B.1-2-3-4-5-6-9-8 and a footnote to B4, the other marked F1-2-3-4-5-6-9-8-9-10-11. I grieve to have caused you so much inconvenience." In very good to fine condition, with seal-related paper loss to the integral address leaf.
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