Russian physiologist known for his work on conditioned reflex through his famous salivating “Pavlov’s Dogs” experiments. He was awarded the 1904 Nobel Prize for Medicine. Vintage fountain pen signature, “Prof. Dr. I. P. Pavlov,” on an off-white 5 x 2 slip affixed to a 6 x 4 off-white album page. In fine condition, with a trivial spot under last initial. COA John Reznikoff/PSA/DNA and R&R COA.